Biology
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URI: http://hdl.handle.net/2144/969
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Targeting the oncogene LSF with either the small molecule inhibitor FQI1 or siRNA causes mitotic delays with unaligned chromosomes, resulting in cell death or senescence
(Springer Science and Business Media LLC, 2020-06-15)BACKGROUND: The oncogene LSF (encoded by TFCP2) has been proposed as a novel therapeutic target for multiple cancers. LSF overexpression in patient tumors correlates with poor prognosis in particular for both hepatocellular ... -
The microtubule-associated histone methyltransferase SET8, facilitated by transcription factor LSF, methylates α-tubulin
(Elsevier BV, 2020-04-03)Microtubules are cytoskeletal structures critical for mitosis, cell motility, and protein and organelle transport and are a validated target for anticancer drugs. However, how tubulins are regulated and recruited to support ... -
Factor quinolinone inhibitors alter cell morphology and motility by destabilizing interphase microtubules
(Springer Science and Business Media LLC, 2021-12-07)Factor quinolinone inhibitors are promising anti-cancer compounds, initially characterized as specific inhibitors of the oncogenic transcription factor LSF (TFCP2). These compounds exert anti-proliferative activity at least ... -
Factor quinolinone inhibitors disrupt spindles and multiple LSF (TFCP2)-protein interactions in mitosis, including with microtubule-associated proteins
(Public Library of Science (PLoS), 2022)Factor quinolinone inhibitors (FQIs), a first-in-class set of small molecule inhibitors targeted to the transcription factor LSF (TFCP2), exhibit promising cancer chemotherapeutic properties. FQI1, the initial lead compound ... -
Transcriptome analysis of cardiac hypertrophic growth in MYBPC3-null mice suggests early responders in hypertrophic remodeling
(FRONTIERS MEDIA SA, 2018-10-25)RATIONALE: With a prevalence of 1 in 200 individuals, hypertrophic cardiomyopathy (HCM) is thought to be the most common genetic cardiac disease, with potential outcomes that include severe hypertrophy, heart failure, and ... -
The function of the MEF2 family of transcription factors in cardiac development, cardiogenomics, and direct reprogramming
(MDPI AG, 2016-09)Proper formation of the mammalian heart requires precise spatiotemporal transcriptional regulation of gene programs in cardiomyocytes. Sophisticated regulatory networks have evolved to not only integrate the activities of ... -
miR-410 and miR-495 are dynamically regulated in diverse cardiomyopathies and their inhibition attenuates pathological hypertrophy
(PUBLIC LIBRARY SCIENCE, 2016-03-21)Noncoding RNAs have emerged as important modulators in cardiac development and pathological remodeling. Recently, we demonstrated that regulation of the Gtl2-Dio3 noncoding RNA locus is dependent on the MEF2 transcription ... -
The key Lnc (RNA)s in cardiac and skeletal muscle development, regeneration, and disease
(MDPI AG, 2021-07-25)Non-coding RNAs (ncRNAs) play a key role in the regulation of transcriptional and epigenetic activity in mammalian cells. Comprehensive analysis of these ncRNAs has revealed sophisticated gene regulatory mechanisms which ... -
A hearty dose of noncoding RNAs: the imprinted DLK1-DIO3 locus in cardiac development and disease
(MDPI AG, 2018-07-10)The imprinted Dlk1-Dio3 genomic region harbors a noncoding RNA cluster encoding over fifty microRNAs (miRNAs), three long noncoding RNAs (lncRNAs), and a small nucleolar RNA (snoRNA) gene array. These distinct noncoding ... -
CMYA5 establishes cardiac dyad architecture and positioning
(Springer Science and Business Media LLC, 2022-04-21)Cardiac excitation-contraction coupling requires dyads, the nanoscopic microdomains formed adjacent to Z-lines by apposition of transverse tubules and junctional sarcoplasmic reticulum. Disruption of dyad architecture and ...
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