MED: Genetics & Genomics Papers
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URI: http://hdl.handle.net/2144/2435
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Telomere Disruption Results in Non-Random Formation of De Novo Dicentric Chromosomes Involving Acrocentric Human Chromosomes
(Public Library of Science, 2010-8-12)Genome rearrangement often produces chromosomes with two centromeres (dicentrics) that are inherently unstable because of bridge formation and breakage during cell division. However, mammalian dicentrics, and particularly ... -
Transferability and Fine-Mapping of Genome-Wide Associated Loci for Adult Height across Human Populations
(Public Library of Science, 2009-12-22)Human height is the prototypical polygenic quantitative trait. Recently, several genetic variants influencing adult height were identified, primarily in individuals of East Asian (Chinese Han or Korean) or European ancestry. ... -
Cofilin Activation in Peripheral CD4 T Cells of HIV-1 Infected Patients: A Pilot Study
(BioMed Central, 2008-10-17)Cofilin is an actin-depolymerizing factor that regulates actin dynamics critical for T cell migration and T cell activation. In unstimulated resting CD4 T cells, cofilin exists largely as a phosphorylated inactive form. ... -
A Genome-Wide Association Study of Hypertension and Blood Pressure in African Americans
(Public Library of Science, 2009-7-17)The evidence for the existence of genetic susceptibility variants for the common form of hypertension ("essential hypertension") remains weak and inconsistent. We sought genetic variants underlying blood pressure (BP) by ... -
Evidence for a "Wattle and Daub" Model of the Cyst Wall of Entamoeba
(Public Library of Science, 2009-7-3)The cyst wall of Entamoeba invadens (Ei), a model for the human pathogen Entamoeba histolytica, is composed of fibrils of chitin and three chitin-binding lectins called Jacob, Jessie3, and chitinase. Here we show chitin, ... -
Molecular Weight Assessment of Proteins in Total Proteome Profiles using 1D-PAGE and LC/MS/MS
(BioMed Central, 2005-6-8)BACKGROUND. The observed molecular weight of a protein on a 1D polyacrylamide gel can provide meaningful insight into its biological function. Differences between a protein's observed molecular weight and that predicted ... -
Integration of Relational and Hierarchical Network Information for Protein Function Prediction
(BioMed Central, 2008-8-22)BACKGROUND. In the current climate of high-throughput computational biology, the inference of a protein's function from related measurements, such as protein-protein interaction relations, has become a canonical task. Most ... -
Reversible and Permanent Effects of Tobacco Smoke Exposure on Airway Epithelial Gene Expression
(BioMed Central, 2007-09-25)Oligonucleotide microarray analysis revealed 175 genes that are differentially expressed in large airway epithelial cells of people who currently smoke compared with those who never smoked, with 28 classified as irreversible, ... -
Lack of Association between Angiotensin-Converting Enzyme and Dementia of the Alzheimer's Type in an Elderly Arab Population in Wadi Ara, Israel
(Dove Medical Press, 2005)The angiotensin-converting enzyme (ACE), a protease involved in blood pressure regulation, has been implicated as an important candidate gene for Alzheimer's disease (AD). This study investigated whether the ACE gene ... -
Previously Unidentified Changes in Renal Cell Carcinoma Gene Expression Identified by Parametric Analysis of Microarray Data
(BioMed Central, 2003-11-27)BACKGROUND. Renal cell carcinoma is a common malignancy that often presents as a metastatic-disease for which there are no effective treatments. To gain insights into the mechanism of renal cell carcinogenesis, a number ...
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