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  Associations of accelerometer-measured physical activity and sedentary time with chronic kidney disease: The Framingham Heart Study 

  Lee, Joowon; Walker, Maura E.; Gabriel, Kelley P.; Vasan, Ramachandran S.; Xanthakis, Vanessa (2020)

  BACKGROUND: Few studies examined the individual and conjoint associations of accelerometer-measured physical activity (PA) and sedentary times with the prevalence of chronic kidney disease (CKD) among older adults. METHODS: ...
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  Klotho pathways, myelination disorders, neurodegenerative diseases, and epigenetic drugs 

  Moos, Walter H.; Faller, Douglas V.; Glavas, Ioannis P.; Harpp, David N.; Kanara, Iphigenia; Mavrakis, Anastasios N.; Pernokas, Julie; Pernokas, Mark; Pinkert, Carl A.; Powers, Whitney R.; Sampani, Konstantina; Steliou, Kosta; Vavvas, Demetrios G.; Zamboni, Robert J.; Kodukula, Krishna; Chen, Xiaohong (Mary Ann Liebert, Inc., 2020)

  In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination ...
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  Epigenetic treatment of dermatologic disorders 

  Moos, Walter H.; Faller, Douglas V.; Glavas, Ioannis P.; Harpp, David N.; Kanara, Iphigenia; Pinkert, Carl A.; Powers, Whitney R.; Sampani, Konstantina; Steliou, Kosta; Vavvas, Demetrios G.; Kodukula, Krishna; Zamboni, Robert J. (Wiley, 2019-09)

  Healthy skin protects us against a multitude of insults but injured or maladapted skin can lead to infection, inflammation or worse. Fortunately, naturally occurring bioactive products, many commonly found in olive oil and ...
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  Epigenetic treatment of persistent viral infections 

  Moos, Walter H.; Pinkert, Carl A.; Irwin, Michael H.; Faller, Douglas V.; Kodukula, Krishna; Glavas, Ioannis P.; Steliou, Kosta (Wiley, 2017-02-01)

  Approximately 2,500 years ago, Hippocrates used the word herpes as a medical term to describe lesions that appeared to creep or crawl on the skin, advocating heat as a possible treatment. During the last 50 years, ...
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  Epigenetic treatment of neuropsychiatric disorders: autism and schizophrenia 

  Moos, Walter H.; Maneta, Eleni; Pinkert, Carl A.; Irwin, Michael H.; Hoffman, Michelle E.; Faller, Douglas V.; Steliou, Kosta (John Wiley & Sons, Inc., 2016-03-01)

  Neuropsychiatric disorders are a heterogeneous group of conditions that often share underlying mitochondrial dysfunction and biological pathways implicated in their pathogenesis, progression, and treatment. To date, these ...
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  Epigenetic treatment of neurodegenerative disorders: Alzheimer and Parkinson diseases 

  Irwin, Michael H.; Moos, Walter H.; Faller, Douglas V.; Steliou, Kosta; Pinkert, Carl A. (Wiley-Blackwell, 2016-05-01)

  In this review we expand our discussion of epigenetic-driven methods for treating neurodegenerative disorders associated with mitochondrial dysfunction, focusing on carnitinoid antioxidant-histone deacetylase inhibitors ...
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  Butyrate histone deacetylase inhibitors. 

  Steliou, Kosta; Boosalis, Michael S.; Perrine, Susan P.; Sangerman, José; Faller, Douglas V. (2012-08)

  In addition to being a part of the metabolic fatty acid fuel cycle, butyrate is also capable of inducing growth arrest in a variety of normal cell types and senescence-like phenotypes in gynecological cancer cells, inhibiting ...
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  Low cost extraction and isothermal amplification of DNA for infectious diarrhea diagnosis 

  Huang, Shichu; Do, Jaephil; Mahalanabis, Madhumita; Fan, Andy; Zhao, Lei; Jepeal, Lisa; Singh, Satish K.; Klapperich, Catherine M. (Public Library of Science, 2013-03-28)

  In order to counter the common perception that molecular diagnostics are too complicated to work in low resource settings, we have performed a difficult sample preparation and DNA amplification protocol using instrumentation ...
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  The multiple hit hypothesis for Gulf War illness: self-reported chemical/biological weapons exposure and mild traumatic brain injury 

  Janulewicz, Patricia; Krengel, Maxine; Quinn, Emily; Heeren, Timothy; Toomey, Rosemary; Killiany, Ronald; Zundel, Clara; Ajama, Joy; O'Callaghan, James; Steele, Lea; Klimas, Nancy; Sullivan, Kimberly (MDPI, 2018-11-01)

  The Gulf War Illness Consortium (GWIC) was designed to identify objective biomarkers of Gulf War Illness (GWI) in 1991 Gulf War veterans. The symptoms of GWI include fatigue, pain, cognitive problems, gastrointestinal, ...
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  LITAF mediation of increased TNF-α secretion from inflamed colonic lamina propria macrophages. 

  Bushell, Kristen N.; Leeman, Susan E.; Gillespie, Earl; Gower, Adam C.; Reed, Karen L.; Stucchi, Arthur F.; Becker, James M.; Amar, Salomon (2011)

  Dysregulation of TNF-α in lamina propria macrophages (LPM) is a feature of inflammatory bowel diseases (IBD). LPS-Induced-TNF-Alpha-Factor (LITAF) is a transcription factor that mediates TNF-α expression. To determine ...

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